On the periodically aggregated particles on the fracture face of the cochlear hair cell.
نویسندگان
چکیده
By means of the freeze-fracture technique, the membrane specialization of the cochlear hair cell of guinea pigs was studied. Periodically aggregated particles were revealed on the PF face of the plasma membrane of the outer hair cell. The particles were around 12 nm in diameter and 10 to 17 nm in center-to-center spacing. Their arragement was hexagonal, orthogonal or parallel. Possible involvement of this structure in the electrical excitability of the membrane was discussed.
منابع مشابه
Therapeutic potential of cell therapy in the repair of hair cells and spiral ganglion neurons: review article
The mammalian cochlea is a highly complex structure which contains several cells, including sensory receptor or hair cells. The main function of the cochlear hair cells is to convert the mechanical vibrations of the sound into electrical signals, then these signals travel to the brain along the auditory nerve. Auditory hair cells in some amphibians, reptiles, fish, and birds can regenerate or r...
متن کاملBending Behavior of Sandwich Plates with Aggregated CNT-Reinforced Face Sheets
The main aim of this paper is to investigate bending behavior in sandwich plates with functionally graded carbon nanotube reinforced composite (FG-CNTRC) face sheets with considering the effects of carbon nanotube (CNT) aggregation. The sandwich plates are assumed resting on Winkler-Pasternak elastic foundation and a mesh-free method based on first order shear deformation theory (FSDT) is devel...
متن کاملThe Effect of Celecoxib, a Cyclooxygenase-2 Inhibitor on Noise- Induced Hearing Loss
Objective(s): Noise-induced hearing loss (NIHL) is the major cause of acquired hearing loss. Celecoxib, a cyclooxygenase-2 (COX-2) inhibitor, is a non- steroidal anti- inflammatory drug (NSAID) with known antioxidant and antineoplastic activity. Therefore, we monitored the extent of temporary noise- induced threshold shifts (TTS) and cochlear damage caused by high level 4- kHz noise exposure t...
متن کاملTricellulin deficiency affects tight junction architecture and cochlear hair cells.
The two compositionally distinct extracellular cochlear fluids, endolymph and perilymph, are separated by tight junctions that outline the scala media and reticular lamina. Mutations in TRIC (also known as MARVELD2), which encodes a tricellular tight junction protein known as tricellulin, lead to nonsyndromic hearing loss (DFNB49). We generated a knockin mouse that carries a mutation orthologou...
متن کاملAssessment of ultrastructure in isolated cochlear hair cells using a procedure for rapid freezing before freeze-fracture and deep-etching.
Separated cochlear outer hair cells and isolated strips of organ of Corti containing hair cells and supporting cells have been rapidly frozen before freeze-fracture and deep-etching by immersion of samples sandwiched between two copper plates into liquid nitrogen-cooled propane: isopentane. Assessment of this procedure has shown that no significant freezing damage occurs. The ultrastructure of ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Archivum histologicum Japonicum = Nihon soshikigaku kiroku
دوره 39 5 شماره
صفحات -
تاریخ انتشار 1976